The investigators jointly decide to add an addendum to the protocol that requires remove data collected from participants who have withdrawn and only analyze data from participants who have completed the intervention.

These are some possible outcomes:

The attrition rate becomes a problem as the study fails to reach the necessary sample size.

The focus of the investigation stays on those participants completing the intervention, with minimal adverse affect.

The focus of the investigation stays on those participants completing the intervention, with substantial adverse affect.