<< Previous Section | < Previous Page | Next Page > | Next Section >> Bibliography (page 2 of 11) Markman, M. (2004). "Ethical Conflict in Providing Informed Consent for Clinical Trials: A Problematic Example from the Gynecologic Cancer Research Community." Oncologist 9(1): 3-7.      This thoughtful article raises a series of ethical dilemmas regarding a study of "consolidation" therapy for women who achieve a complete clinical remission of ovarian carcinoma. They use the actual conduct of the experiment as the basis for discussion and also introduce the special responsibilities of the initial major study to be as complete as possible. http://theoncologist.alphamedpress.org/cgi/content/full/9/1/3 Ross, L. F. (2003). "Responding to the Challenge of the Children's Health Act: An Introduction to Children in Research." Theoretical Medicine and Bioethics 24(2): 101.      This article summarizes the arguments in this issue of theoretical medicine regarding the challenge of the Children's Health Act of 2001 that provided both funding and the opportunity to loosen restrictions on research with children. it clearly summarizes sophisticated arguments and could introduce the field to a novice. http://www.springerlink.com/openurl.asp?genre=article &id=doi:10.1023/A:1024650410202 Rothmier, J. D., M. V. Lasley, et al. (2003). "Factors Influencing Parental Consent in Pediatric Clinical Research." Pediatrics 111(5): 1037-1041.      In research with small children one might ask why are parents consenting. This study queries 44 parents or guardians regarding volunteering their children and found that the leading reason was neither altruism nor free medications, but rather to learn more about the disease. Nicely done. http://pediatrics.aappublications.org/cgi/content/full/111/5/1037 Katzman, D. K. (2003). "Guidelines for adolescent health research." Journal of Adolescent Health 33(5): 410.      This is an excellent description of the need for research on adolescents, their ability to consent, and the federal rules as interpreted for adolescents. http://www.sciencedirect.com/science/article/B6T80-49W1YBN -G/2/a66b9af2a5f68c67a6695a167276dbcd Macklin, R. (2000). "Informed consent for research: international perspectives." J Am Med Womens Assoc 55(5): 290-3.      A brief and thoughtful analysis of two conditions under which women are treated unethically in becoming research participants, not being fully informed and having a husband also sign the consent form. She doesn't buy into either condition. Hougham, G., G. Sachs, et al. (2003). "Empirical research on informed consent with the cognitively impaired." IRB Ethics and Human Research 25(5): S26-S32.      This paper briefly describes research on informed in a great variety of cognitively impaired subjects at a number of institutions. While the data are not given conclusions derived from these studies are presented. Many cognitively-impaired individuals retain the capacity to make informed participation decisions. Consent is a longitudinal process with involvement of surrogates at every point. One should never ignore the wishes of impaired subjects. This paper provides useful insights and a number of the papers should be out by now. Spriggs, M. (2004). "Canaries in the mines: children, risk, non-therapeutic research, and justice." J Med Ethics 30(2): 176-181.      This report discusses the Kennedy-Krieger lead point study and why it was unethical, using insights different from matters of risk. Very worthwhile in considering what is good science. << Previous Section | < Previous Page | Next Page > | Next Section >> Chapter 3 Quick Links Ethics and Study Design Introductory Ethics Design Appropriate Risk to Benefit Ratio Selection of Subject Populations Cases Bibliography Chapter 3 Download (PDF)