Animal Subjects |  | The IACUC & ARO at UNH (cont.) | 10 of 16
Introduction Case Study Philosophies & Principles Regulations & Guidelines IACUC & ARO at UNH Responsibilities Case Study Review |  |  | Project directors who meet these requirements will have addressed the three Rs: Replacement: Substitution of non-animal models or lower species Reduction: Use of minimum number of animals necessary to answer the research question or demonstrate the activity Refinement: Reduction of incidence or severity of pain and distress experienced by the animals through appropriate anesthetics and analgesics
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